A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1
A. Closa, M. Reixachs-Sole, A. C. Fuentes-Fayos, K. E. Hayer, J. L. Melero, F. R. Adriaanse, R. S. Bos, M. Torres-Diz, S. Hunger, K. G. Roberts, C. Mullighan, R. W. Stam, A. Thomas-Tikhonenko, J. P. Castano, R. M. Luque, E. Eyras
The paper identifies a convergent malignant phenotype in infant B-ALL linked to SRRM1 upregulation and splicing alterations, independent of gene fusions.
bioRxiv · Dec 13, 2021 · PreprintCancer Biology