Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
M. T. Diz, C. Reglero, C. D. Falkenstein, A. Castro, K. E. Hayer, C. Radens, M. Quesnel-Vallieres, Z. Ang, P. Sehgal, M. M. Li, Y. Barash, S. K. Tasian, A. Ferrando, A. Thomas-Tikhonenko
The paper identifies an alternatively spliced NT5C2 isoform contributing to chemoresistance in B-ALL by enhancing nucleosidase activity and 6-MP resistance.
bioRxiv · Sep 14, 2023Cancer Biology
C. H. Danan, K. E. Naughton, K. E. Hayer, S. Vellapan, E. A. McMillan, Y. Zhou, R. Matsuda, S. K. Nettleford, K. Katada, L. R. Parham, X. Ma, A. Chowdhury, B. J. Wilkins, P. Shah, M. D. Weitzman, K. E. Hamilton
This study shows METTL3 is essential for survival of intestinal transit amplifying cells, maintaining growth factor signaling and KRAS expression, and its deletion leads to intestinal atrophy and death.
bioRxiv · Apr 6, 2023 · PreprintCell Biology
Z. Ang, L. Paruzzo, K. E. Hayer, C. Schmidt, M. Torres Diz, F. Xu, U. Zankharia, Y. Zhang, S. Soldan, S. Zheng, C. D. Falkenstein, J. P. Loftus, S. Y. Yang, M. Asnani, P. King Sainos, , A. Thomas-Tikhonenko
This study identifies alternative splicing of CD20 mRNA that generates translation-deficient isoforms, contributing to resistance to CD20-directed immunotherapies.
bioRxiv · Feb 19, 2023Immunology
S. Y. Yang, K. E. Hayer, H. Fazelinia, M. Asnani, K. L. Black, A. S. Naqvi, V. Pillai, L. A. Spruce, Y. Barash, K. S. Elenitoba-Johnson, A. Thomas-Tikhonenko
The paper identifies FBXW7β as a predominant isoform in normal and malignant pro-B cells, showing it drives a proinflammatory TNF gene cluster.
bioRxiv · Apr 24, 2022 · PreprintCell Biology
A. Closa, M. Reixachs-Sole, A. C. Fuentes-Fayos, K. E. Hayer, J. L. Melero, F. R. Adriaanse, R. S. Bos, M. Torres-Diz, S. Hunger, K. G. Roberts, C. Mullighan, R. W. Stam, A. Thomas-Tikhonenko, J. P. Castano, R. M. Luque, E. Eyras
The paper identifies a convergent malignant phenotype in infant B-ALL linked to SRRM1 upregulation and splicing alterations, independent of gene fusions.
bioRxiv · Dec 13, 2021 · PreprintCancer Biology
P. Sehgal, C. Lanauze, X. Wang, K. E. Hayer, M. Torres-Diz, Y. Sela, B. Z. Stanger, C. J. Lengner, A. Thomas-Tikhonenko
This study shows MYC enhances WNT signaling in colorectal cancer cells by repressing DKK3 via miR-92a, creating an oncogenic feedback loop.
bioRxiv · Jul 26, 2021Cancer Biology
C. Herrmann, J. M. Dybas, J. C. Liddle, A. M. Price, K. E. Hayer, R. Lauman, C. E. Purman, M. Charman, E. T. Kim, B. A. Garcia, M. D. Weitzman
The paper identifies RNA-binding proteins as substrates of viral-mediated ubiquitination, showing that non-degradative ubiquitination enhances viral RNA processing and progeny production.
bioRxiv · Jun 5, 2020Microbiology
G. S. Wu, K. S. Yang-Iott, M. A. Reed, K. E. Hayer, K. D. Lee, C. H. Bassing
The paper shows that poor quality Vβ RSSs limit Vβ recombination, enforcing allelic exclusion by reducing functional rearrangements on both alleles before feedback inhibition.
bioRxiv · Jan 20, 2020Immunology
A. M. Price, K. E. Hayer, D. P. Depledge, A. C. Wilson, M. D. Weitzman
This study uses long-read RNA sequencing to identify novel adenovirus transcripts and splice variants not detectable by short-read methods.
bioRxiv · Dec 13, 2019 · PreprintMicrobiology
K. L. Black, A. S. Naqvi, K. E. Hayer, S. Y. Yang, E. Gillespie, A. Bagashev, V. Pillai, S. Tasian, M. R. Gazzara, M. Carroll, D. Taylor, K. W. Lynch, Y. Barash, A. Thomas-Tikhonenko
The paper identifies widespread aberrant splicing in pediatric B-ALL, showing that splicing factor deregulation drives splicing changes and contributes to disease.
Nucleic Acids Research · Oct 24, 2018Peer-reviewedCancer Biology