Author

A. Thomas-Tikhonenko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Assay:bulk RNA-seq· 7 Research Focus:differential expression· 6 Approach:statistical model· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

K. E. Hayer· 6 shared Y. Barash· 5 shared P. Sehgal· 3 shared S. Y. Yang· 3 shared V. Pillai· 3 shared A. S. Naqvi· 2 shared B. Z. Stanger· 2 shared C. D. Falkenstein· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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6 shared papersCancer Biology

K. E. Hayer

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Author profile →

8 papers

Recent·Most cited

An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia

M. T. Diz, C. Reglero, C. D. Falkenstein, A. Castro, K. E. Hayer, C. Radens, M. Quesnel-Vallieres, Z. Ang, P. Sehgal, M. M. Li, Y. Barash, S. K. Tasian, A. Ferrando, A. Thomas-Tikhonenko

The paper identifies an alternatively spliced NT5C2 isoform contributing to chemoresistance in B-ALL by enhancing nucleosidase activity and 6-MP resistance.

bioRxiv · Sep 14, 2023Cancer Biology

Alternative splicing of its 5'-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

Z. Ang, L. Paruzzo, K. E. Hayer, C. Schmidt, M. Torres Diz, F. Xu, U. Zankharia, Y. Zhang, S. Soldan, S. Zheng, C. D. Falkenstein, J. P. Loftus, S. Y. Yang, M. Asnani, P. King Sainos, , A. Thomas-Tikhonenko

This study identifies alternative splicing of CD20 mRNA that generates translation-deficient isoforms, contributing to resistance to CD20-directed immunotherapies.

bioRxiv · Feb 19, 2023Immunology

Mapping and modeling human colorectal carcinoma interactions with the tumor microenvironment

N. Li, Q. Zhu, Y. Tian, K. J. Ahn, X. Wang, Z. Cramer, I. W. Folkert, P. Yu, J. Jou, S. Adams-Tzivelekidis, P. Sehgal, N. N. Mahmoud, C. B. Aarons, R. E. Roses, A. Thomas-Tikhonenko, , C. J. Lengner

This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.

bioRxiv · Sep 13, 2022Cancer Biology

FBXW7β isoform drives transcriptional activation of a proinflammatory TNF cluster in normal and malignant pro-B cells

S. Y. Yang, K. E. Hayer, H. Fazelinia, M. Asnani, K. L. Black, A. S. Naqvi, V. Pillai, L. A. Spruce, Y. Barash, K. S. Elenitoba-Johnson, A. Thomas-Tikhonenko

The paper identifies FBXW7β as a predominant isoform in normal and malignant pro-B cells, showing it drives a proinflammatory TNF gene cluster.

bioRxiv · Apr 24, 2022 · PreprintCell Biology

A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1

A. Closa, M. Reixachs-Sole, A. C. Fuentes-Fayos, K. E. Hayer, J. L. Melero, F. R. Adriaanse, R. S. Bos, M. Torres-Diz, S. Hunger, K. G. Roberts, C. Mullighan, R. W. Stam, A. Thomas-Tikhonenko, J. P. Castano, R. M. Luque, E. Eyras

The paper identifies a convergent malignant phenotype in infant B-ALL linked to SRRM1 upregulation and splicing alterations, independent of gene fusions.

bioRxiv · Dec 13, 2021 · PreprintCancer Biology

Identifying common transcriptome signatures of cancer by interpreting deep learning models

A. Jha, M. Quesnel-Vallieres, A. Thomas-Tikhonenko, K. W. Lynch, Y. Barash

This study identifies common transcriptome signatures across cancer types using deep learning models trained on RNA-Seq data, revealing genes and splicing variations associated with cancer.

bioRxiv · Nov 11, 2021Cancer Biology

MYC hyperactivates WNT signaling in APC/CTNNB1-mutated colorectal cancer cells through miR-92a-dependent repression of DKK3

P. Sehgal, C. Lanauze, X. Wang, K. E. Hayer, M. Torres-Diz, Y. Sela, B. Z. Stanger, C. J. Lengner, A. Thomas-Tikhonenko

This study shows MYC enhances WNT signaling in colorectal cancer cells by repressing DKK3 via miR-92a, creating an oncogenic feedback loop.

bioRxiv · Jul 26, 2021Cancer Biology

Aberrant splicing in B-cell acute lymphoblastic leukemia

K. L. Black, A. S. Naqvi, K. E. Hayer, S. Y. Yang, E. Gillespie, A. Bagashev, V. Pillai, S. Tasian, M. R. Gazzara, M. Carroll, D. Taylor, K. W. Lynch, Y. Barash, A. Thomas-Tikhonenko

The paper identifies widespread aberrant splicing in pediatric B-ALL, showing that splicing factor deregulation drives splicing changes and contributes to disease.

Nucleic Acids Research · Oct 24, 2018Peer-reviewedCancer Biology