J. L. Ortega-Roldan

Elucidation of small molecule passive permeation across lipid membranes using conventional solution state NMR methods

This paper develops an NMR-based assay to measure small molecule permeation across lipid membranes, applied to antimicrobial candidates.

Zn2+ triggered two-step mechanism of CLIC1 membrane insertion and activation into chloride channels

This study identifies Zn2+ binding as the molecular switch for CLIC1 membrane insertion and pH-dependent chloride efflux activation.

Membrane insertion of soluble CLIC1 into active chloride channels is triggered by specific divalent cations

This paper identifies Ca2+ and Zn2+ binding as the molecular switch triggering CLIC1 membrane insertion into active chloride channels.