AGC Kinase Inhibitors Regulate STING Signaling Through SGK-Dependent and SGK-Independent Mechanisms
J. V. C. Cabrera, H. Dang, Z. Zhang, J. L. Torres-Castillo, K. Li, P. Liu, J. Aube, B. Damania, R. S. Hagan, A. S. Baldwin
This study identifies Sanofi-14h, an AGC kinase inhibitor, as a regulator of STING signaling that acts through both SGK-dependent and SGK-independent mechanisms to suppress IFNβ expression.
bioRxiv · Jul 21, 2022 · PreprintImmunology