H. Dang

Prolonged airway explant culture enables study of health, disease, and viral pathogenesis

This study develops methods to culture human and animal airway explants for at least 14 days, preserving tissue architecture and enabling study of health, disease, and viral infection.

The Emerging Role of 3-Hydroxyanthranilic Acid on C. elegans Aging Immune Function

This paper investigates how 3HAA and haao-1 inhibition affect C. elegans immune function and aging, finding that 3HAA improves immune function and acts as an antimicrobial against gram-negative bacteria.

SICKO: Systematic Imaging of Caenorhabditis Killing Organisms

SICKO enables longitudinal tracking of microbial colonization and host survival in C. elegans, revealing that gut colonization by E. coli or Pseudomonas aeruginosa shortens lifespan and that pmk-1-deficient animals are more susceptible.

Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants

The paper shows that cross-reactive antibodies, like S309, retain effector functions against emerging Omicron variants despite reduced neutralization.

The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions

This study shows that Apold1 is not essential for normal angiogenesis but is critical for revascularization under ischemic conditions and tumor growth.

AGC Kinase Inhibitors Regulate STING Signaling Through SGK-Dependent and SGK-Independent Mechanisms

This study identifies Sanofi-14h, an AGC kinase inhibitor, as a regulator of STING signaling that acts through both SGK-dependent and SGK-independent mechanisms to suppress IFNβ expression.

A model of persistent post SARS-CoV-2 induced lung disease for target identification and testing of therapeutic strategies

This paper develops a murine model of persistent post-SARS-CoV-2 lung disease to identify therapeutic targets and test interventions for PASC.

Revisiting colorectal cancer tumorigenesis with spatially-resolved gene expression profiling

This study uses spatially-resolved gene expression profiling to analyze molecular changes in colorectal cancer from healthy tissue to cancer, identifying potential biomarkers and highlighting the role of the innate immune system.

Robust W1282X-CFTR rescue by a small molecule GSPT1 degrader

The paper develops Bmi-1/hTERT cell lines to model CFTR variants and shows that CC-90009 partially rescues W1282X-CFTR function while affecting sodium channel activity.

Fine-tuning of SUMOylation modulates drought tolerance

This study shows that both increased and decreased SUMOylation enhance drought tolerance in apple by modulating MdDREB2A stability through SUMOylation and ubiquitination.