J. Laine

Body-wide genetic deficiency of poly(ADP-ribose) polymerase 14 sensitizes mice to colitis

This study shows that Parp14 deficiency in mice worsens colitis by impairing epithelial barrier integrity and altering inflammation-related gene expression.

The actin-spectrin submembrane scaffold restricts endocytosis along proximal axons

The paper investigates how the actin-spectrin scaffold in axons regulates clathrin-mediated endocytosis, finding that spectrin clearings restrict pit formation and endocytic activity.

Caveolae and Bin1 form ring-shaped platforms for T-tubule initiation

This study shows that caveolae and Bin1 form ring-shaped structures that initiate T-tubule formation in muscle cells.

Mutational dynamics and transmission properties of SARS-CoV-2 superspreading events in Austria

This study analyzes SARS-CoV-2 superspreading events in Austria using genomic and epidemiological data to understand viral transmission and mutation dynamics.

Guanabenz treatment improves Oculopharyngeal muscular dystrophy phenotype

This study shows that guanabenz acetate reduces PABPN1 aggregates and improves muscle function in an OPMD mouse model by modulating the UPR.

Mechanosensitive clathrin platforms anchor desmin intermediate filaments in skeletal muscle

This study shows that clathrin plaques and dynamin 2 anchor desmin intermediate filaments and regulate YAP signaling in skeletal muscle in response to mechanical cues.