Author

O. Pich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:whole-genome sequencing· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:clustering· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2

Frequent Co-Authors

N. Lopez-Bigas· 4 shared A. Gonzalez-Perez· 2 shared E. Gronroos· 2 shared F. Muinos· 2 shared A. Ben Aissa· 1 shared A. Bergthaler· 1 shared A. Cortes-Bullich· 1 shared A. D. Yates· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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4 shared papersCancer Biology

N. Lopez-Bigas

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Genomic evolution of non-small cell lung cancer patient-derived xenograft models

R. E. Hynds, A. Huebner, D. R. Pearce, A. U. Akarca, D. A. Moore, S. Ward, K. H. C. Gowers, T. Karasaki, M. S. Hill, M. Al Bakir, G. A. Wilson, O. Pich, M. Sivakumar, A. Ben Aissa, E. Gronroos, , C. Swanton

This study examines how well PDX models capture intratumour heterogeneity in NSCLC, finding that most models originate from a single subclone but regional models can capture diversity.

bioRxiv · Jan 6, 2023Cancer Biology

Targeted cancer therapy induces APOBEC fuelling the evolution of drug resistance

D. R. Caswell, M. K. Mayekar, P. Gui, E. K. Law, N. I. Vokes, C. M. Ruiz, M. Dietzen, M. Angelova, C. Bailey, O. Pich, B. Bakker, W. Wu, T. J. Humpton, D. L. Kerr, W. Hill, , Argyr

This study shows that targeted cancer therapy induces APOBEC-mediated mutagenesis, promoting drug resistance by increasing genetic diversity through mechanisms involving NF-κB activation and reduced DNA repair.

bioRxiv · Dec 18, 2020Cancer Biology

Mutational dynamics and transmission properties of SARS-CoV-2 superspreading events in Austria

A. Popa, J.-W. Genger, M. Nicholson, T. Penz, D. Schmid, S. W. Aberle, B. Agerer, A. Lercher, L. Endler, H. Colaco, M. Smyth, M. Schuster, M. Grau, F. Martinez Jimenez, O. Pich, , A. Bergthaler

This study analyzes SARS-CoV-2 superspreading events in Austria using genomic and epidemiological data to understand viral transmission and mutation dynamics.

Science Translational Medicine · Dec 9, 2020Peer-reviewedMicrobiology

The evolution of hematopoietic cells under cancer therapy

O. Pich, A. Cortes-Bullich, F. Muinos, M. Pratcorona, A. Gonzalez-Perez, N. Lopez-Bigas

This study investigates how chemotherapy influences the mutation burden and clonal expansion in hematopoietic cells, finding that platinum-based drugs leave a mutational footprint while 5-FU does not.

bioRxiv · Oct 29, 2020Cancer Biology

In silico saturation mutagenesis of cancer genes

F. Muinos, F. Martinez-Jimenez, O. Pich, A. Gonzalez-Perez, N. Lopez-Bigas

This study uses in silico saturation mutagenesis to identify driver mutations in 568 cancer genes across 66 tumor types, revealing how mutation probability and selection influence observed variants.

bioRxiv · Jun 3, 2020Cancer Biology

Pervasive lesion segregation shapes cancer genome evolution

S. J. Aitken, C. J. Anderson, F. Connor, O. Pich, V. Sundaram, C. Feig, T. F. Rayner, M. Lukk, S. Aitken, J. Luft, E. Kentepozidou, C. Arnedo-Pac, S. Beentjes, S. E. Davies, R. M. Drews, , M. S. Taylor

This study shows that DNA lesions segregate between daughter cells, leading to chromosome-scale mutation phasing and increased genetic diversity in cancer genomes.

bioRxiv · Dec 8, 2019Cancer Biology