The Endosomal pH Regulator NHE9 is a Driver of Stemness in Glioblastoma
M. Ko, M. R. Makena, P. V. Schiapparelli, P. Suarez Meade, A. X. Mekile, B. Lal, H. Lopez-Bertoni, J. Laterra, A. Quinones-Hinojosa, R. Rao
This paper identifies NHE9 as a driver of stemness in glioblastoma by showing it increases receptor tyrosine kinase stability and activates JAK2-STAT3 to induce pluripotency genes.
bioRxiv · Oct 7, 2021Cancer Biology