Author

A. X. Mekile

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

M. R. Makena· 3 shared R. Rao· 3 shared M. Ko· 2 shared A. Quinones-Hinojosa· 1 shared B. Lal· 1 shared C. J. White· 1 shared C. Talbot· 1 shared D. K. Dang· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

M. R. Makena

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The Endosomal pH Regulator NHE6 is Required for Insulin-Stimulated Glucose Uptake in Adipocytes

A. X. Mekile, M. R. Makena, R. Gupta, C. J. White, R. W. Bowman, R. L. Patnayak, D. N. Lorenzo, R. Rao

This study shows that NHE6 is essential for insulin-stimulated glucose uptake in adipocytes by regulating GLUT4 trafficking and expression.

bioRxiv · Jul 30, 2023 · PreprintPhysiology

The Endosomal pH Regulator NHE9 is a Driver of Stemness in Glioblastoma

M. Ko, M. R. Makena, P. V. Schiapparelli, P. Suarez Meade, A. X. Mekile, B. Lal, H. Lopez-Bertoni, J. Laterra, A. Quinones-Hinojosa, R. Rao

This paper identifies NHE9 as a driver of stemness in glioblastoma by showing it increases receptor tyrosine kinase stability and activates JAK2-STAT3 to induce pluripotency genes.

bioRxiv · Oct 7, 2021Cancer Biology

Store Independent Ca2+ Entry Regulates the DNA Damage Response in Breast Cancer Cells

M. R. Makena, M. Ko, A. X. Mekile, D. K. Dang, J. M. Warrington, P. J. Buckhaults, C. Talbot, R. Rao

This study identifies SPCA2 as a driver of chemotherapy resistance in ER+/p53WT breast cancer by suppressing the DNA damage response through store-independent Ca2+ entry.

bioRxiv · Apr 6, 2020 · PreprintCancer Biology