Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis
J. Lizarrondo, D. P. Klebl, S. Niebling, M. Abella, M. A. Schroer, H. D. T. Mertens, K. Veith, D. I. Svergun, M. Skruzny, F. Sobott, S. Muench, M. M. Garcia-Alai
The paper presents a cryoEM structure of a 16-mer complex from Sla2 and Ent1, showing how they anchor to the plasma membrane during clathrin-mediated endocytosis and highlights the importance of their interactions for efficient membrane invagination.
bioRxiv · Nov 3, 2020Biophysics