D. I. Svergun

Determinants of receptor tyrosine phosphatase homophilic adhesion: structural comparison of PTPRK and PTPRM extracellular domains

This study compares the structural features of PTPRK and PTPRM extracellular domains to identify determinants of homophilic adhesion, finding that shape complementarity and limited sequence differences drive specificity.

Herpes simplex virus 1 protein pUL21 stimulates cellular ceramide transport by activating CERT

This paper shows HSV-1 protein pUL21 activates CERT to increase ceramide to sphingomyelin conversion, but does not affect virus replication or spread.

Cryo-EM structure of an atypical proton-coupled peptide transporter: Di- and tripeptide permease C

This study determines the cryo-EM structure of DtpC, an atypical proton-coupled peptide transporter, revealing structural insights into its ligand selectivity.

Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF

The paper shows that the acidic domain of APLF assembles histone octamers and deposits them onto DNA to form nucleosomes.

N-terminal phosphorylation regulates the activity of Glycogen Synthase Kinase 3 from Plasmodium falciparum

This study identifies N-terminal phosphorylation sites in PfGSK3 that regulate its activity through conformational changes, offering insights into malarial parasite biology.

pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread

This study identifies pUL21 as a viral phosphatase adaptor that promotes HSV-1 replication and spread by directing dephosphorylation and antagonizing pUS3 kinase activity.

A non-structural pure enzyme protein forms an LCST type of stimuli-responsive and reversible hydrogel with novel structure and catalytic activity

This paper reports a unique enzyme, LplA, that forms a stimuli-responsive and reversible hydrogel with catalytic activity, revealing its structural and functional mechanisms.

Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis

The paper presents a cryoEM structure of a 16-mer complex from Sla2 and Ent1, showing how they anchor to the plasma membrane during clathrin-mediated endocytosis and highlights the importance of their interactions for efficient membrane invagination.

The allosteric modulation of Complement C5 by knob domain peptides

This study shows that knob domain peptides modulate complement C5 through allosteric mechanisms, revealing new therapeutic inhibitors and introducing knob domains as low molecular weight antibody fragments.

Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats

This study investigates MORN repeat proteins, revealing they are protein-protein interaction modules rather than lipid-binding modules, based on structural and functional analyses of TbMORN1 and homologs.

Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

This study isolates and characterizes synthetic nanobodies that neutralize SARS-CoV-2, identifying Sb23 with high affinity and neutralization activity.

Structure-based identification and functional characterization of an essential lipocalin in the malaria parasite Plasmodium falciparum

This study identifies and characterizes PfLCN, a lipocalin in Plasmodium falciparum, showing its role in oxidative stress response and parasite survival.

Structure of herpes simplex virus pUL7:pUL51, a conserved complex required for efficient herpesvirus assembly

This paper solves the structure of the HSV-1 pUL7:pUL51 complex, showing its conservation across herpesviruses and its potential role in membrane remodeling during virus assembly.

Utilisation of staphylococcal immune evasion protein Sbi as a novel vaccine adjuvant

This paper demonstrates that the Staphylococcal protein Sbi can be used as a vaccine adjuvant by promoting natural opsonisation of antigens with C3 fragments, enhancing immune responses.

Functional interaction of low-homology FRPs from different cyanobacteria with Synechocystis OCP

The paper investigates the functional interaction of low-homology FRPs from different cyanobacteria with Synechocystis OCP, revealing distinct binding properties despite similar structural conformations.