Author

D. P. Klebl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 5 Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:protein folding & dynamics· 4 Research Focus:chromatin & epigenetic regulation· 2 Approach:microscopy & imaging analysis· 2 Organism:E. coli· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

S. P. Muench· 6 shared F. Sobott· 5 shared H. D. White· 3 shared D. Kontziampasis· 2 shared M. S. C. Gravett· 2 shared M. Trebbin· 2 shared A. Flynn· 1 shared B. Virok· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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6 shared papersBiochemistry

S. P. Muench

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Swinging lever mechanism of myosin directly demonstrated by time-resolved cryoEM

D. P. Klebl, S. N. McMillan, C. Risi, E. Forgacs, B. Virok, J. Atherton, M. Stofella, D. Winkelmann, F. Sobott, V. Galkin, P. J. Knight, S. P. Muench, C. Scarff, H. D. White

This paper uses time-resolved cryoEM to directly observe the swinging lever mechanism of myosin-5, showing its structural changes during ATP hydrolysis and force generation.

bioRxiv · Jan 5, 2024 · PreprintBiochemistry

Exploiting the Affimer platform against influenza A virus

O. Debski-Antoniak, A. Flynn, D. P. Klebl, C. Tiede, I. A. Wilson, S. P. Muench, D. Tomlinson, J. Fontana

This paper isolates and characterizes Affimers, antibody-like proteins, that inhibit influenza A virus H3 subtype infection in vitro and block HA-receptor interactions.

bioRxiv · Aug 22, 2023Microbiology

Exploiting cryo-EM structures of actomyosin-5a to reveal the physical properties of its lever

M. S. C. Gravett, D. P. Klebl, O. G. Harlen, D. J. Read, S. A. Harris, S. P. Muench, M. Peckham

This study uses cryo-EM and molecular dynamics to determine the structure and physical properties of Myo5a's lever, revealing its working stroke and implications for its walking mechanism.

bioRxiv · Mar 19, 2023Biophysics

The bacterial magnesium transporter MgtA reveals highly selective interaction with specific cardiolipin species

J. Weikum, J. Vandyck, S. Subramani, D. P. Klebl, M. Storflor, s. P. muench, S. Abel, F. Sobott, J. P. Morth

This study shows that the bacterial magnesium transporter MgtA has functional specificity for cardiolipin species, with maximum activity achieved when combining cardiolipin 16:0 and 18:1.

bioRxiv · Sep 27, 2021Biochemistry

Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis

J. Lizarrondo, D. P. Klebl, S. Niebling, M. Abella, M. A. Schroer, H. D. T. Mertens, K. Veith, D. I. Svergun, M. Skruzny, F. Sobott, S. Muench, M. M. Garcia-Alai

The paper presents a cryoEM structure of a 16-mer complex from Sla2 and Ent1, showing how they anchor to the plasma membrane during clathrin-mediated endocytosis and highlights the importance of their interactions for efficient membrane invagination.

bioRxiv · Nov 3, 2020Biophysics

Need for speed: Examining protein behaviour during cryoEM grid preparation at different timescales

D. P. Klebl, M. S. C. Gravett, D. Kontziampasis, D. J. Wright, R. S. Bon, D. Monteiro, M. Trebbin, F. Sobott, H. D. White, M. Darrow, R. F. Thompson, s. P. muench

This study examines how different macromolecular complexes behave during cryoEM grid preparation at various timescales using three vitrification devices.

bioRxiv · May 14, 2020Biochemistry

A Cryo-EM Grid Preparation Device for Time-Resolved Structural Studies

D. Kontziampasis, D. P. Klebl, M. G. Iadanza, C. A. Scarff, F. Kopf, F. Sobott, D. C. F. Monteiro, M. Trebbin, S. P. Muench, H. D. White

This paper introduces a cryo-EM grid preparation device that enables rapid mixing and vitrification, achieving sub 4 Å reconstructions for time-resolved structural studies.

bioRxiv · Mar 4, 2019Biophysics