iPSC-derived Cancer Organoids Recapitulate Genomic and Phenotypic Alterations of c-met-mutated Hereditary Kidney Cancer
J. W. Hwang, C. Desterke, O. Feraud, S. Richard, S. Ferlicot, V. Verkarre, J. J. Patard, J. Loisel-Duwattez, A. Foudi, F. Griscelli, A. Bennaceur Griscelli, A. G. Turhan
The paper generates c-met-mutated iPSC-derived kidney organoids that recapitulate genomic and phenotypic features of PRCC, identifying common genes and validating their expression in both organoids and patient tumors.
bioRxiv · Jan 11, 2019 · PreprintCancer Biology