Author

A. G. Turhan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

C. Desterke· 5 shared A. Bennaceur-Griscelli· 3 shared A. Foudi· 3 shared A. Bennaceur Griscelli· 2 shared I. Simanic· 2 shared J. Artus· 2 shared S. Coignard· 2 shared Y. Ijjeh· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersCancer Biology

C. Desterke

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5 papers

Recent·Most cited

Modeling Global Genomic Instability in Chronic Myeloid Leukemia (CML) using patient-derived induced pluripotent stem cells (iPSC)

G. Telliam, C. Desterke, J. Imeri, R. Mkacher, N. Oudrhiri, E. Balducci, M. Arnoux, H. Acloque, A. Bennaceur-Griscelli, A. G. Turhan

This study uses patient-derived iPSCs with in vitro mutagenesis to model genomic instability in CML, identifying aberrations linked to blast crisis progression.

Cancers · May 3, 2023Peer-reviewedCancer Biology

BCR-ABL promotes hematopoietic stem and progenitor cell formation in embryonic stem cells

J. Artus, A. Zenych, I. Simanic, C. Desterke, D. Clay, S. Saim, Y. Ijjeh, L. E. B. de Souza, S. Coignard, A. Bennaceur-Griscelli, A. G. Turhan, A. Foudi

This study shows that BCR-ABL expression in murine ESCs promotes the formation and maintenance of hematopoietic progenitors with a molecular signature similar to wild-type HSCs.

bioRxiv · Feb 3, 2023Cancer Biology

miR-495-3p Sensitizes BCR::ABL1 Expressing Leukemic cells to Tyrosine Kinase Inhibitors by Targeting Multidrug Resistance 1 Gene including in T315I Mutated cells

Y. Rittavee, J. Artus, C. Desterke, I. Simanic, L. Eduardo Botelho de Souza, S. Riccaldi, S. Coignard, Y. Ijjeh, P. Hugues, A. Bennaceur Griscelli, A. G. Turhan, A. Foudi

This study shows miR-495-3p reduces CML cell growth and TKI resistance by targeting MDR1, especially in T315I-mutant cells, and identifies it as a potential therapeutic target.

Experimental Hematology · Feb 1, 2023Peer-reviewedCancer Biology

ENOX2 NADH Oxidase: A BCR-ABL1-dependent cell surface and secreted redox protein in chronic myeloid leukemia (CML)

S. Baykal Kose, M. Voldoire, C. Desterke, N. Sorel, E. Cayssials, H. Johnson-Ansah, A. Guerci-Bresler, A. Bennaceur-Griscelli, J. C. Chomel, A. G. Turhan

This study identifies ENOX2 as a BCR-ABL1-dependent secreted redox protein upregulated in CML, with increased expression in patient plasma and cell lines.

bioRxiv · Jan 23, 2021Cancer Biology

iPSC-derived Cancer Organoids Recapitulate Genomic and Phenotypic Alterations of c-met-mutated Hereditary Kidney Cancer

J. W. Hwang, C. Desterke, O. Feraud, S. Richard, S. Ferlicot, V. Verkarre, J. J. Patard, J. Loisel-Duwattez, A. Foudi, F. Griscelli, A. Bennaceur Griscelli, A. G. Turhan

The paper generates c-met-mutated iPSC-derived kidney organoids that recapitulate genomic and phenotypic features of PRCC, identifying common genes and validating their expression in both organoids and patient tumors.

bioRxiv · Jan 11, 2019 · PreprintCancer Biology