Cross-species metabolomic analysis of DDT and Alzheimer's disease-associated tau toxicity
V. Kalia, M. M. Niedzwiecki, J. M. Bradner, F. K. Lau, M. L. Bucher, K. E. Manz, Z. Coates Fuentes, K. D. Pennell, M. Picard, D. I. Walker, W. T. Hu, D. P. Jones, G. W. Miller
This study investigates the link between DDT exposure and tau toxicity in C. elegans and humans, finding that DDT exacerbates mitochondrial dysfunction caused by tau aggregation.
bioRxiv · Jun 14, 2021 · PreprintPharmacology & Toxicology