M. Picard

The impact of physical activity on physical performance, mitochondrial bioenergetics, ROS production and calcium handling across the human adult lifespan

The paper examines how physical activity affects mitochondrial function, ROS production, and calcium handling in skeletal muscle across the human lifespan, finding that aging does not reduce mitochondrial respiration but decreases calcium retention capacity.

The energetic stress cytokine GDF15 is elevated in the context of chronic and acute psychosocial stress

This paper shows that GDF15 levels rise with psychosocial stress, depression, anxiety, and biological aging, and that saliva GDF15 has a distinct diurnal pattern and responds rapidly to acute stress.

Psychosocial experiences are associated with human brain mitochondrial biology

This study links psychosocial experiences to mitochondrial biology in the human brain, finding positive experiences correlate with higher OxPhos machinery abundance and negative experiences with lower abundance.

Accelerated physiology and increased energy expenditure in animals and humans with mitochondrial defects: A meta-analysis

This study meta-analyzes energy expenditure in mitochondrial defect models, finding elevated energy costs in 51% of animal studies and similar trends in humans, suggesting hypermetabolism.

Cellular Allostatic Load is linked to Increased Energy Expenditure and Accelerated Biological Aging

The paper shows chronic glucocorticoid exposure increases cellular energy expenditure and accelerates aging in human fibroblasts.

Targeted spectroscopy in the eye fundus

This paper demonstrates targeted ocular spectroscopy for imaging and spectral analysis of the eye fundus, showing its ability to detect biomarkers and assess blood oxygen saturation in vivo.

Glucocorticoid and adrenergic receptor distribution across human organs and tissues: a map for stress transduction

This study maps glucocorticoid and adrenergic receptor expression across human organs, showing tissue-specific patterns and their link to mitochondrial pathways in stress responses.

Accelerating the clock: Interconnected speedup of energetic and molecular dynamics during aging in cultured human cells

This study shows that human cells age faster when they consume energy more rapidly, linking metabolic rate to molecular aging markers across the lifespan.

Leukocyte cytokine responses in adult patients with mitochondrial DNA defects

This study examines cytokine responses and glucocorticoid sensitivity in leukocytes from patients with mitochondrial DNA defects, finding reduced IL-6 and IL-1β responses to LPS in those with mtDNA deletions.

OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases

The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.

A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations

The paper presents a longitudinal multi-omics dataset of human fibroblasts with mitochondrial perturbations to study aging mechanisms and bioenergetics.

Mitochondrial Respiratory Chain Protein Co-Regulation in the Human Brain

The paper characterizes co-regulation patterns of mitochondrial respiratory chain proteins in the human brain across three cohorts, finding differential co-regulation between nuclear and mitochondrial DNA-encoded subunits and reduced complex I abundance in Alzheimer's disease.

Cross-species metabolomic analysis of DDT and Alzheimer's disease-associated tau toxicity

This study investigates the link between DDT exposure and tau toxicity in C. elegans and humans, finding that DDT exacerbates mitochondrial dysfunction caused by tau aggregation.

Ovarian Tumor Mitochondria Exhibit Abnormal Phenotypes and Blunted Associations with Biobehavioral Factors

The paper examines mitochondrial content and function in ovarian tumors and their associations with biobehavioral factors, finding abnormal mitochondrial phenotypes and weaker biobehavioral correlations in tumors.

Mitochondrial phenotypes in purified human immune cell subtypes and cell mixtures

The paper quantifies mitochondrial features in purified human immune cell subtypes and mixed cell populations, revealing age- and sex-related differences and confounding effects of cell type distribution and platelets.

An automated, high throughput methodology optimized for quantitative cell-free mitochondrial and nuclear DNA isolation from plasma

The paper optimizes an automated high-throughput method for isolating cell-free mitochondrial and nuclear DNA from plasma, achieving 6-fold higher yields of mitochondrial DNA.

Quantum dot probes for the quantitative study of drug transport by the MacAB TolC efflux pump in lipid scaffolds

The paper demonstrates high coupling efficiency of drug transport and ATP hydrolysis by the MacAB-TolC efflux pump using a lipid scaffold and spectroscopic monitoring.

Quantitative Mapping of Human Hair Graying and Reversal in Relation to Life Stress

This study quantifies hair graying and its reversal in humans, linking it to stress and showing proteomic and computational evidence of reversibility.

Human Aging DNA Methylation Signatures are Conserved but Accelerated in Cultured Fibroblasts