V. Kalia

Versatile Tissue-Injectable Hydrogels with Extended Hydrolytic Release of Bioactive Protein Therapeutics

This paper develops injectable hydrogels that enable controlled, extended release of protein therapeutics through hydrolysable linkers, demonstrating efficacy in a mouse melanoma model.

IFNγ modestly contributes to disease progression in the Ndufs4(-/-) model of Leigh syndrome while IP10 is dispensable

Tempered IL-2 Signals Program PD-1 Checkpoint Blockade-Responsive Stem-like Exhausted T Cells During Priming

This study shows that tempered IL-2 signals promote the development of PD-1 checkpoint blockade-responsive stem-like exhausted CD8 T cells during priming, while strong IL-2 signals drive terminal differentiation.

Peripheral macrophages causally contribute to disease onset and progression in the Ndufs4(KO) model of Leigh syndrome

This study shows that peripheral macrophages contribute to CNS lesions in the Ndufs4(-/-) Leigh syndrome model, despite microglia depletion having limited effect.

A novel fluorobenzothiazole RBx 10080758 as a dual inhibitor against bacterial GyraseB (GyrB) and Topoisomerase IV (parE) of Gram-positive pathogens causing skin and respiratory infections

This paper evaluates a novel fluorobenzothiazole inhibitor, RBx 10080758, showing potent in vitro and in vivo activity against drug-resistant Gram-positive bacteria by dual targeting Gyrase B and Topoisomerase IV.

Novel modification of Luminex assay for characterization of extracellular vesicle populations in biofluids.

This paper introduces a novel Luminex-based immunoassay for multiplexed detection of EV surface proteins without requiring EV purification, demonstrating its ability to differentiate EVs from erythrocytes, macrophages, and neurons.

Evidences for newer insecticides and growth regulators resistance in field populations of Helicoverpa armigera (Lepidoptera: Noctuidae) in Karnataka, India

The paper investigates insecticide and growth regulator resistance in Helicoverpa armigera populations in Karnataka, India, finding higher resistance to Novaluran and newer insecticides.

Cross-species metabolomic analysis of DDT and Alzheimer's disease-associated tau toxicity

This study investigates the link between DDT exposure and tau toxicity in C. elegans and humans, finding that DDT exacerbates mitochondrial dysfunction caused by tau aggregation.

Development of a novel Francisella tularensis Live Vaccine Strain expressing ovalbumin provides insight into Francisella tularensis-specific CD8+ T cell responses.

This paper develops a novel F. tularensis vaccine strain expressing ovalbumin to study CD8+ T cell responses, finding that these cells expand early, produce IFN-γ, and have distinct kinetics in different tissues.