Ambra1 haploinsufficiency results in metabolic alterations and exacerbates age-associated retinal degeneration
I. Ramirez-Pardo, B. Villarejo-Zori, J. I. Jimenez-Loygorri, E. Sierra-Filardi, S. Alonso-Gil, G. Marino, P. de la Villa, P. S. Fitze, J. M. Fuentes, R. Garcia-Escudero, R. Gomez-Sintes, P. Boya
This study shows that reduced Ambra1 levels in mice lead to metabolic issues and faster retinal degeneration, suggesting autophagy's role in protecting against aging-related vision loss.
bioRxiv · Feb 4, 2022 · PreprintCell Biology