Author

R. Garcia-Escudero

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Organism:mouse· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:differential expression· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

R. Errazquin· 3 shared C. Lorz· 2 shared C. Segrelles· 2 shared J. Peral· 2 shared J. Surralles· 2 shared A. Asensio· 1 shared A. Ayuso-Sacido· 1 shared A. B. Enguita· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCancer Biology

R. Errazquin

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The G-Protein Couple Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis

A. Asensio, M. Sanz-Flores, K. Liakath-Ali, J. Palacios, J. M. Paramio, R. Garcia-Escudero, F. Mayor, C. Ribas

This study identifies GRK2's role in hair follicle homeostasis by showing its deletion leads to cyst formation, stem cell disruption, and hair loss in mice.

bioRxiv · Apr 11, 2024Cell Biology

Non-viral CRISPR/Cas9 Mutagenesis for Streamlined Generation of Mouse Lung Cancer Models

I. Lara-Saez, A. Mencia, E. Recuero, Y. Li, M. Garcia, M. Oteo, M. I. Gallego, A. B. Enguita, D. de Prado-Verdun, S. A, W. Wang, R. Garcia-Escudero, R. Murillas, M. Santos

This paper introduces a non-viral CRISPR/Cas9 method using cationic polymers to generate mouse lung cancer models by inactivating tumor suppressor genes, enabling rapid and flexible hypothesis testing.

bioRxiv · Dec 21, 2023 · PreprintCancer Biology

Fanconi anemia-isogenic head and neck cancer cell line pairs - a basic and translational science resource

H. T. Nguyen, W. Tang, A. L. H. Webster, J. R. Whiteaker, C. M. Chandler, R. Errazquin, L. B. Sullivan, E. Jonlin, E. E. Hoskins, E. Y. Chen, M. Fritzke, A. G. Paulovich, S. I. Wells, K. Roohollahi, J. Dorsman, , R. J. Monnat

The paper develops isogenic head and neck cancer cell line pairs to study Fanconi anemia-associated cancers and their treatment.

bioRxiv · Sep 11, 2022Cancer Biology

Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemia

R. Errazquin, A. Page, A. Sunol, C. Segrelles, E. Carrasco, J. Peral, A. Garrido-Aranda, S. Del Marro, J. Ortiz, C. Lorz, J. Minguillon, J. Surralles, C. Belendez, M. Alvarez, J. Balmana, , R. Garcia-Escudero

This paper develops a mouse model of spontaneous oral squamous cell carcinoma in Fanconi anemia by combining Fanca gene knockout with conditional Trp53 deletion in oral mucosa.

bioRxiv · Jun 5, 2022Cancer Biology

Ambra1 haploinsufficiency results in metabolic alterations and exacerbates age-associated retinal degeneration

I. Ramirez-Pardo, B. Villarejo-Zori, J. I. Jimenez-Loygorri, E. Sierra-Filardi, S. Alonso-Gil, G. Marino, P. de la Villa, P. S. Fitze, J. M. Fuentes, R. Garcia-Escudero, R. Gomez-Sintes, P. Boya

This study shows that reduced Ambra1 levels in mice lead to metabolic issues and faster retinal degeneration, suggesting autophagy's role in protecting against aging-related vision loss.

bioRxiv · Feb 4, 2022 · PreprintCell Biology

Generating new FANCA-deficient HNSCC cell lines by genomic editing recapitulate the cellular phenotypes of Fanconi anemia

R. Errazquin, E. Sieiro, P. Moreno, M. J. Ramirez, C. Lorz, J. Peral, J. A. Casado, F. J. Roman-Rodriguez, H. Hanenber, P. Rio, J. Surralles, C. Segrelles, R. Garcia-Escudero

The paper generates FANCA-deficient HNSCC cell lines using CRISPR/Cas9 and shows they recapitulate FA-related cellular phenotypes.

bioRxiv · Oct 3, 2020Cancer Biology

IDH-Tau-EGFR triad defines the neovascular landscape of diffuse gliomas by controlling mesenchymal differentiation

R. Gargini, B. Segura-Collar, V. Garcia-Escudero, A. Romero-Bravo, B. Herranz, F. J. Nunez, D. Garcia-Perez, A. Ayuso-Sacido, J. Seoane, J. M. Sepulveda-Sanchez, A. Hernandez-Lain, M. G. Castro, R. Garcia-Escudero, J. Avila, P. Sanchez-Gomez, , A. Perez-Nunez

This study identifies the IDH-Tau-EGFR triad as a key factor in defining the neovascular landscape of diffuse gliomas by regulating mesenchymal differentiation and vascular microenvironment.

bioRxiv · Oct 3, 2019Cancer Biology

Prostaglandin F2α-induced TGFβ-PMEPA1 pathway is a critical mediator of epithelial plasticity and ovarian carcinoma progression.

A. Jimenez-Segovia, A. Mota, A. Rojo-Sebastian, B. Barrocal, A. Rynne-Vidal, M. L. Garcia-Bermejo, R. Gomez-Bris, L. J. A. C. Hawinkels, P. Sandoval, R. Garcia-Escudero, M. Lopez-Cabrera, G. Moreno-Bueno, M. Fresno, K. Stamatakis

This paper identifies PGF2α-induced TGFβ-PMEPA1 pathway as a driver of epithelial plasticity and ovarian cancer progression, with PMEPA1 as a therapeutic target and prognostic biomarker.

bioRxiv · Sep 18, 2018Cancer Biology