Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming
C. V. Maduka, M. Alhaj, E. Ural, M. O. Habeeb, M. M. Kuhnert, K. Smith, A. V. Makela, H. Pope, S. Chen, J. M. Hix, C. L. Mallet, S.-J. Chung, M. Hakun, A. Tundo, K. R. Zinn, , C. H. Contag
This study shows that PLA degradation products reprogram cell metabolism, leading to immune activation and inflammation, and demonstrates that targeting metabolism can reduce inflammation and improve biocompatibility.
bioRxiv · Sep 22, 2022Bioengineering