A. V. Makela

Magnetic particle imaging reveals that iron-labeled extracellular vesicles accumulate in brains of mice with metastases

This paper uses magnetic particle imaging to show that iron-labeled extracellular vesicles accumulate in brains of mice with brain metastases but not in mice without metastases.

Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells

This study demonstrates targeted intracellular delivery of molecular cargo to hypoxic breast cancer stem cells using GlaS, a protein that binds phosphatidylserine and delivers payloads under hypoxic conditions.

Regulating the proinflammatory response to implanted composite biomaterials comprising polylactide and hydroxyapatite by targeting immunometabolism

This study modulates the inflammatory response to PLA-HA biomaterials by targeting immunometabolism, reducing proinflammatory cells and increasing pro-regenerative ones.

Immunometabolic cues recompose and reprogram the microenvironment around biomaterials

The paper shows that immunometabolic cues around biomaterials influence immune cell trafficking and microenvironment composition, promoting a pro-regenerative state through metabolic reprogramming.

Elevated oxidative phosphorylation is critical for immune cell activation by polyethylene wear particles

The paper shows that elevated oxidative phosphorylation in macrophages exposed to polyethylene particles increases ROS and proinflammatory cytokines, suggesting a role in inflammation and implant failure.

Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming

This study shows that PLA degradation products reprogram cell metabolism, leading to immune activation and inflammation, and demonstrates that targeting metabolism can reduce inflammation and improve biocompatibility.

Magnetothermal control of temperature-sensitive repressors in superparamagnetic iron nanoparticle-coated Bacillus subtilis

This study uses superparamagnetic iron oxide nanoparticles and alternating magnetic fields to control temperature-sensitive repressors in Bacillus subtilis, demonstrating magnetothermal regulation of gene expression.

MPI region of interest (ROI) analysis and quantification of iron in different volumes

The paper evaluates four MPI ROI selection methods for iron quantification in vitro and in vivo, finding trade-offs between ROI size and accuracy.

Magnetic particle imaging of magnetotactic bacteria as living contrast agents is improved by altering magnetosome structures

The paper improves magnetic particle imaging by modifying magnetosome structures in magnetotactic bacteria, resulting in enhanced MPI signals and resolution.

Tracking the fates of iron-labeled tumor cells in vivo using Magnetic Particle Imaging

This study uses Magnetic Particle Imaging to track iron-labeled tumor cells in vivo, revealing their movement and accumulation, and confirms their presence in tissues through histology.

Engineered endosymbionts capable of directing mammalian cell gene expression

This paper develops engineered endosymbionts that direct mammalian gene expression by secreting transcription factors into the host cell nucleus.

Development of Magnetic Particle Imaging (MPI) for Cell Tracking and Detection

This paper demonstrates the use of magnetic particle imaging (MPI) for tracking and detecting superparamagnetic iron oxide nanoparticle-labeled cells in mice, showing higher sensitivity compared to MRI.