C. H. Contag

Magnetic particle imaging reveals that iron-labeled extracellular vesicles accumulate in brains of mice with metastases

This paper uses magnetic particle imaging to show that iron-labeled extracellular vesicles accumulate in brains of mice with brain metastases but not in mice without metastases.

Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells

This study demonstrates targeted intracellular delivery of molecular cargo to hypoxic breast cancer stem cells using GlaS, a protein that binds phosphatidylserine and delivers payloads under hypoxic conditions.

Regulating the proinflammatory response to implanted composite biomaterials comprising polylactide and hydroxyapatite by targeting immunometabolism

This study modulates the inflammatory response to PLA-HA biomaterials by targeting immunometabolism, reducing proinflammatory cells and increasing pro-regenerative ones.

Immunometabolic cues recompose and reprogram the microenvironment around biomaterials

The paper shows that immunometabolic cues around biomaterials influence immune cell trafficking and microenvironment composition, promoting a pro-regenerative state through metabolic reprogramming.

Flavinated SDHA Underlies the Change in Intrinsic Optical Properties of Oral Cancers

The paper identifies flavinated SDHA as responsible for altered autofluorescence in oral cancer cells, linking it to metabolic changes and potential diagnostic and therapeutic targets.

First Biodegradable Bioactive Glass-based Humidity Sensor

This paper develops a biodegradable bioactive glass-based humidity sensor that detects hydration changes, useful for monitoring brain edema and intracranial pressure.

Stereochemistry Determines Immune Cellular Responses to Polylactide Implants

This study shows that PLA stereochemistry affects immune responses through differential metabolic changes in macrophages and fibroblasts, with stereocomplex PLA increasing proinflammatory cytokines via glycolysis.

Elevated oxidative phosphorylation is critical for immune cell activation by polyethylene wear particles

The paper shows that elevated oxidative phosphorylation in macrophages exposed to polyethylene particles increases ROS and proinflammatory cytokines, suggesting a role in inflammation and implant failure.

Glycolytic reprogramming underlies immune cell activation by polyethylene wear particles

The paper shows that polyethylene particles alter immune cell metabolism, leading to glycolytic reprogramming and inflammation, which can be inhibited to promote bone integration.

Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming

This study shows that PLA degradation products reprogram cell metabolism, leading to immune activation and inflammation, and demonstrates that targeting metabolism can reduce inflammation and improve biocompatibility.

Magnetothermal control of temperature-sensitive repressors in superparamagnetic iron nanoparticle-coated Bacillus subtilis

This study uses superparamagnetic iron oxide nanoparticles and alternating magnetic fields to control temperature-sensitive repressors in Bacillus subtilis, demonstrating magnetothermal regulation of gene expression.

Gla-domain mediated targeting of externalized phosphatidylserine for intracellular delivery

This paper describes a GLA-domain that binds externalized phosphatidylserine and enables rapid, energy-independent intracellular delivery of probes in animal models.

Harnessing insect olfactory neural circuits for noninvasive detection of human cancer

This paper uses insect olfactory neural circuits to detect human oral cancers by analyzing VOCs from cell cultures, achieving fast and reliable classification.

Magnetic particle imaging of magnetotactic bacteria as living contrast agents is improved by altering magnetosome structures

The paper improves magnetic particle imaging by modifying magnetosome structures in magnetotactic bacteria, resulting in enhanced MPI signals and resolution.

A New Bioink For Improved 3D Bioprinting Of Bone-Like Constructs

This study develops a new bioink, GelMA-Ag-BaG, for 3D bioprinting of bone-like constructs, showing improved homogeneity, rheology, and degradation compared to existing materials.

Tracking the fates of iron-labeled tumor cells in vivo using Magnetic Particle Imaging

This study uses Magnetic Particle Imaging to track iron-labeled tumor cells in vivo, revealing their movement and accumulation, and confirms their presence in tissues through histology.

Engineered endosymbionts capable of directing mammalian cell gene expression

This paper develops engineered endosymbionts that direct mammalian gene expression by secreting transcription factors into the host cell nucleus.