K. D. Hankenson

Maladaptive immune-fibrotic axis drives impaired long bone regeneration under mechanical instability

This study shows that mechanical instability causes fibrosis and immune dysregulation, impairing bone healing in fractures.

Regulating the proinflammatory response to implanted composite biomaterials comprising polylactide and hydroxyapatite by targeting immunometabolism

This study modulates the inflammatory response to PLA-HA biomaterials by targeting immunometabolism, reducing proinflammatory cells and increasing pro-regenerative ones.

Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing

This study shows that Lgr6 is essential for osteogenesis and fracture healing by maintaining bone volume and promoting stem cell activity in mice.

Stereochemistry Determines Immune Cellular Responses to Polylactide Implants

This study shows that PLA stereochemistry affects immune responses through differential metabolic changes in macrophages and fibroblasts, with stereocomplex PLA increasing proinflammatory cytokines via glycolysis.

Polylactide Degradation Activates Immune Cells by Metabolic Reprogramming

This study shows that PLA degradation products reprogram cell metabolism, leading to immune activation and inflammation, and demonstrates that targeting metabolism can reduce inflammation and improve biocompatibility.

Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 to drive osteoarthritis

This study identifies distinct synovial fibroblast subsets in PTOA and shows that Prg4hi fibroblasts secrete Rspo2 to drive pathological crosstalk.

Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

This study shows that BMAd lipolysis is essential for maintaining myelopoiesis, bone mass, and bone regeneration during energy deficits.