A Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2
J. T. Hampton, T. J. Lalonde, J. M. Tharp, Y. R. Alugubelli, C. M. Roundy, G. L. Hamer, S. Xu, W. R. Liu, Y. Kurra
This study constructs and validates a phage-displayed macrocyclic peptide library using regioselective chemical reactions and identifies a potent SARS-CoV-2 neutralizing peptide through epitope-directed selection.
bioRxiv · Jul 6, 2022Biochemistry