Author

J. T. Hampton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

S. Xu· 3 shared W. R. Liu· 3 shared L. D. Sylvain· 2 shared P.-H. C. Chen· 2 shared Y. R. Alugubelli· 2 shared C. A. Fierke· 1 shared C. M. Roundy· 1 shared C.-C. Cho· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiochemistry

S. Xu

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3 papers

Recent·Most cited

An Amber-Encoding Helper Phage for More Efficient Phage Display of Noncanonical Amino Acids

J. T. Hampton, C.-C. Cho, Z. Z. Geng, D. D. Coleman, P.-H. C. Chen, G. K. Dubey, L. D. Sylvain, S. Xu, W. R. Liu

This paper introduces a novel helper phage, CMa13ile40, that improves the efficiency of phage display by enabling rapid enrichment of amber codon-containing phage clones and enhancing the production of noncanonical amino acid (ncAA)-containing phages.

Nucleic Acids Research · Jun 9, 2023Peer-reviewedBiochemistry

Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor

J. S. Morse, Y. J. Sheng, J. T. Hampton, L. D. Sylvain, S. Das, Y. R. Alugubelli, P.-H. C. Chen, K. S. Yang, S. Xu, C. A. Fierke, W. R. Liu

This paper develops PADLE, a phage-assisted method to evolve potent HDAC8 inhibitors, identifying two highly selective and potent inhibitors with sub-nanomolar Ki values.

bioRxiv · Sep 14, 2022Biochemistry

A Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2

J. T. Hampton, T. J. Lalonde, J. M. Tharp, Y. R. Alugubelli, C. M. Roundy, G. L. Hamer, S. Xu, W. R. Liu, Y. Kurra

This study constructs and validates a phage-displayed macrocyclic peptide library using regioselective chemical reactions and identifies a potent SARS-CoV-2 neutralizing peptide through epitope-directed selection.

bioRxiv · Jul 6, 2022Biochemistry