Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number
J. M. Tkach, R. Philip, A. Sharma, J. Strecker, D. Durocher, L. Pelletier
The paper identifies TRIM37 as a key mediator of growth arrest after PLK4 inhibition and shows that growth arrest correlates with PLK4 activity rather than mitotic length or centrosome number.
bioRxiv · Jun 25, 2021Cell Biology