L. Pelletier

Beta-catenin mediates growth defects induced by centrosome loss in APC mutant colorectal cancer independently of p53

The paper shows that beta-catenin, not p53, mediates growth defects from centrosome loss in APC-mutant colorectal cancer organoids.

Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.

This study shows that PCM1 and centriolar satellites are essential for efficient ciliogenesis by facilitating protein trafficking and remodeling of the mother centriole.

Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number

The paper identifies TRIM37 as a key mediator of growth arrest after PLK4 inhibition and shows that growth arrest correlates with PLK4 activity rather than mitotic length or centrosome number.

The CP110-CEP97-CEP290 module orchestrates a centriolar satellite dependent response to proteotoxic stress

The paper identifies the CP110-CEP97-CEP290 module's role in centriolar satellite-dependent aggresome formation and its importance in proteotoxic stress response and disease protein aggregation.

Comparison of SARS-CoV-2 Indirect and Direct Detection Methods

This paper compares indirect and direct SARS-CoV-2 detection methods, finding that BGI's system is most sensitive but costly, while direct methods are less sensitive but faster and cheaper.

LUZP1 and the tumour suppressor EPLIN are negative regulators of primary cilia formation

This study identifies LUZP1 and EPLIN as negative regulators of primary cilia formation by modulating actin dynamics at the centrosome and basal body.