Author

J. M. Vose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. L. Smith· 2 shared C. R. D'Angelo· 2 shared A. A. de Cubas· 1 shared A. Eiken· 1 shared A. Kallam· 1 shared A. Kalluchi· 1 shared A. Krishna· 1 shared A. Natarajan· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

A. L. Smith

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2 papers

Recent·Most cited

Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

A. Eiken, A. L. Smith, S. A. Skupa, E. Schmitz, S. Rana, S. Singh, S. Kumar, J. R. Mallareddy, A. A. de Cubas, A. Krishna, A. Kalluchi, J. Rowley, C. R. D'Angelo, M. A. Lunning, R. G. Bociek, , D. ElGamal

This paper evaluates SpiD3, a novel spirocyclic dimer, showing potent anti-leukemic effects in CLL cells, including resistance to ibrutinib, by targeting NF-κB signaling and the UPR.

bioRxiv · Jan 31, 2024Cancer Biology

A novel triple-action inhibitor targeting B-cell receptor signaling and BRD4 demonstrates preclinical activity in chronic lymphocytic leukemia

A. L. Smith, A. P. Eiken, D. Y. Moore, L. T. Umeta, L. M. Smith, E. R. Lyden, C. R. D'Angelo, A. Kallam, J. M. Vose, T. G. Kutateladze, D. El-Gamal

This study shows that SRX3305, a triple-action inhibitor targeting BTK, PI3K, and BRD4, reduces CLL cell proliferation, promotes apoptosis, and blocks migration in preclinical models.

bioRxiv · May 11, 2022Cancer Biology