S. Rana

Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses

The paper identifies regulatory T cells as mediators of resistance to KRAS-G12C inhibitors and anti-PD-1 therapy through spatial proteomic analysis of lung cancer models.

Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

This paper evaluates SpiD3, a novel spirocyclic dimer, showing potent anti-leukemic effects in CLL cells, including resistance to ibrutinib, by targeting NF-κB signaling and the UPR.

Combining RASG12C(ON) inhibitor with SHP2 inhibition sensitises immune excluded lung tumours to immune checkpoint blockade: a strategy for turning cold tumours hot

This paper shows that combining RASG12C(ON) and SHP2 inhibitors can make cold lung tumors responsive to immune checkpoint blockade by altering the tumor microenvironment and enhancing anti-tumor immunity.

Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

This study shows ivermectin reduces SARS-CoV-2 viral burden in vitro but at concentrations that also cause cytotoxicity, suggesting its antiviral effect may be due to nonspecific membrane perturbation rather than specific antiviral activity.

CRISPR/Cas9 screen identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer

The paper identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer through CRISPR/Cas9 screening and shows targeting COX-2 enhances immune checkpoint blockade efficacy.

SifA SUMOylation governs Salmonella intracellular survival via modulation of lysosomal function

This study shows that SUMOylation of SifA in Salmonella Typhimurium is essential for intracellular survival by modulating lysosomal function and SIF formation.

Single-gene resolution of diversity-driven community overyielding

The paper identifies a gene, AtSUC8, whose allelic differences contribute to increased productivity in mixed Arabidopsis thaliana genotypes by affecting root growth sensitivity to substrate pH.

Therapeutic KRASG12C inhibition drives effective interferon-mediated anti-tumour immunity in immunogenic lung cancers

KRASG12C inhibition enhances anti-tumour immunity in immunogenic lung cancers by upregulating interferon signaling through Myc repression, but only synergizes with immune checkpoint blockade in highly immunogenic models.

A morpho-transcriptomic map of brassinosteroid action in the Arabidopsis root

This study combines morphological and transcriptomic analyses to show brassinosteroid signaling regulates cell division orientation and anisotropic expansion in Arabidopsis roots, with non-cell-autonomous effects on root anatomy.

Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow

The paper optimises an imaging mass cytometry workflow to study TME remodelling in mouse models after KRAS G12C inhibitor treatment.

An immunogenic model of KRAS-mutant lung cancer for study of targeted therapy and immunotherapy combinations

This paper develops an immunogenic mouse model of KRAS-mutant lung cancer that responds to immunotherapy and reveals immune responses target endogenous retroviral antigens rather than neoantigens.

Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via modulation of acid sphingomyelinase

This study shows that miR-15a regulates SMPD1 in endothelial cells, affecting angiogenesis and tumor growth in response to radiation.

MicroRNA-451a regulates colorectal cancer radiosensitivity

This study identifies miR-451a as a regulator of colorectal cancer radiosensitivity, showing it inhibits proliferation and enhances radiation response.