Photoredox-catalyzed decarboxylative C-terminal differentiation for bulk and single molecule proteomics
L. Zhang, B. M. Floyd, M. Chilamari, J. Mapes, J. Swaminathan, S. Bloom, E. M. Marcotte, E. V. Anslyn
This paper introduces a photoredox-catalyzed method for C-terminal labeling of peptides, applicable to bulk and single-molecule proteomics, achieving over 50% labeling efficiency across proteomes.
bioRxiv · Jul 8, 2021Biochemistry