Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
12 papers
Recent·Most cited
C. L. McCafferty, O. Papoulas, C. Lee, K. H. L. Bui, D. W. Taylor, E. M. Marcotte, J. B. Wallingford
The paper defines an amino acid-resolution interactome of motile cilia using XL/MS in Tetrahymena thermophila, revealing structural and functional insights into ciliary machines and ciliopathy proteins.
bioRxiv · Jul 9, 2023 · PreprintCell Biology
A. Ghanaeian, S. Majhi, C. L. McCafferty, B. Nami, C. S. Black, S. K. Yang, T. Legal, O. Papoulas, M. Janowska, M. Valente-Paterno, E. M. Marcotte, D. Wloga, K. H. Bui
The paper uses cryo-EM and integrative modeling to localize DRC subunits in the N-DRC of Tetrahymena thermophila and identifies interacting coiled-coil proteins.
bioRxiv · May 31, 2023Cell Biology
j. leggere, J. Hibbard, O. Papoulas, c. Lee, C. G. Pearson, E. M. Marcotte, J. B. Wallingford
The paper applies DIFFRAC to study proteomic changes in Ift122 mutants of Tetrahymena thermophila, revealing both ciliary and non-ciliary effects of IFT-A loss.
bioRxiv · Mar 8, 2023Cell Biology
C. L. McCafferty, O. Papoulas, M. A. Jordan, G. Hoogerbrugge, C. Nichols, G. Pigino, D. W. Taylor, J. B. Wallingford, E. M. Marcotte
The paper models the structure of the IFT-A complex using experimental and computational methods, revealing insights into ciliopathy-associated mutations.
bioRxiv · Jul 5, 2022Biochemistry
L. Zhang, B. M. Floyd, M. Chilamari, J. Mapes, J. Swaminathan, S. Bloom, E. M. Marcotte, E. V. Anslyn
This paper introduces a photoredox-catalyzed method for C-terminal labeling of peptides, applicable to bulk and single-molecule proteomics, achieving over 50% labeling efficiency across proteomes.
bioRxiv · Jul 8, 2021Biochemistry
C. L. McCafferty, D. W. Taylor, E. M. Marcotte
The paper improves integrative 3D modeling of low- to medium-resolution EM structures using evolutionary couplings to better fit atomic models into EM maps.
bioRxiv · Jan 14, 2021 · PreprintBiochemistry
C. J. Howard, B. M. Floyd, A. M. Bardo, J. Swaminathan, E. M. Marcotte, E. V. Anslyn
This paper introduces a solid-phase peptide capture method for bulk and single-molecule proteomics, demonstrating its effectiveness in isolating and modifying peptides from cell lysates.
bioRxiv · Jan 13, 2020Biochemistry
R. K. Garge, J. M. Laurent, A. H. Kachroo, E. M. Marcotte
The paper humanizes yeast cytoskeletal genes with human duplicates to assess functional redundancy and divergence, finding only a few human genes can replace yeast orthologs in essential functions.
bioRxiv · Dec 16, 2019Evolutionary Biology
E. J. Verbeke, Y. Zhou, A. P. Horton, A. L. Mallam, D. W. Taylor, E. M. Marcotte
The paper develops a method to separate distinct macromolecular structures from heterogeneous cryo-EM data by using common lines in a graphical framework, enabling ab initio 3D structure reconstruction without stringent purification.
bioRxiv · Apr 30, 2019Biochemistry
B. Liebeskind, R. W. Aldrich, E. M. Marcotte
The paper infers ancestral states and evolutionary dynamics of protein-interaction networks using phylogenetic latent variable models and mass spectrometry data.
bioRxiv · Sep 9, 2018Evolutionary Biology
A. I. Teufel, M. M. Johnson, J. M. Laurent, A. H. Kachroo, E. M. Marcotte, C. O. Wilke
This study investigates how gene duplication affects the evolution of interacting proteins, finding that duplicated genes can drive unexpected functional changes in their partners through dosage imbalance.
bioRxiv · Jul 10, 2018Evolutionary Biology
E. J. Verbeke, A. L. Mallam, K. Drew, E. M. Marcotte, D. W. Taylor
The paper uses shotgun EM combined with mass spectrometry to classify single particles from human cell extracts, revealing native proteasome structures and an unknown ~1 MDa complex.
bioRxiv · Jan 14, 2018Biochemistry