Mouse models for pancreatic ductal adenocarcinoma are affected by the cre-driver used to promote KRASG12D activation.
F. Mousavi, J. Thompson, J. Lau, N. Renollet, M. B. Martin, J. McGue, T. Frankel, P. Shooshtari, C. L. Pin, F. Bednar
This study compares mouse models of pancreatic ductal adenocarcinoma driven by different cre-recombinase systems, finding differences in tumor development and inflammation.
bioRxiv · Sep 12, 2023 · PreprintCancer Biology