Author

E. S. Carpenter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 5 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Assay:metabolomics· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Pasca Di Magliano· 5 shared K. L. Donahue· 3 shared A. Andren· 2 shared A. Rao· 2 shared C. A. Lyssiotis· 2 shared C. J. Halbrook· 2 shared F. Bednar· 2 shared H. C. Crawford· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersCancer Biology

M. Pasca Di Magliano

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions

E. S. Carpenter, A. M. Elhossiny, P. Kadiyala, J. Li, J. McGue, B. Griffith, Y. Zhang, J. Edwards, S. Nelson, F. Lima, K. L. Donahue, W. Du, A. C. Bischoff, D. Alomari, H. Watkoske, , M. Pasca Di Magliano

The paper analyzes donor pancreata to define the transcriptomic signature and microenvironment of early pre-neoplastic lesions, finding PanIN lesions are common in healthy individuals and show transcriptional similarity to cancer cells.

bioRxiv · Jan 13, 2023 · PreprintCancer Biology

Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer

W. Yan, N. G. Steele, S. B. Kemp, R. E. Menjivar, W. Du, E. S. Carpenter, K. L. Donahue, K. L. Brown, V. Irizarry-Negron, S. Yang, W. R. Burns, Y. Zhang, M. Pasca di Magliano, F. Bednar

This study shows Notch signaling in tumor-associated macrophages promotes immunosuppression in pancreatic cancer, and blocking it enhances immune therapy effectiveness.

bioRxiv · Jan 11, 2023Cancer Biology

Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer

A. Mello, T. Ngodup, Y. Lee, K. L. Donahue, J. Li, A. Rao, E. S. Carpenter, H. C. Crawford, M. Pasca di Magliano, K. E. Lee

This study shows hypoxia drives an inflammatory phenotype in pancreatic cancer-associated fibroblasts, promoting tumor IL1 expression and iCAF formation in hypoxic regions.

bioRxiv · May 5, 2022Cancer Biology

Nutrient profiling reveals extracellular uridine as a fuel for pancreatic cancer through uridine phosphorylase 1

M. H. Ward, Z. C. Nwosu, P. Poudel, S. Kasperek, Z. Tolstyka, R. E. Menjivar, C. Ragulan, G. Nyamundanda, L. Zhang, A. Andren, C. J. Halbrook, E. S. Carpenter, M. Pasca di Magliano, A. Sadanandam, C. A. Lyssiotis

This study identifies uridine as a novel nutrient for pancreatic cancer cells through uridine phosphorylase 1, showing its role in survival and metabolism under glucose deprivation.

bioRxiv · Jun 7, 2021 · PreprintCancer Biology

GOT1 Inhibition Primes Pancreatic Cancer for Ferroptosis through the Autophagic Release of Labile Iron

D. M. Kremer, B. S. Nelson, L. Lin, E. Yarosz, C. J. Halbrook, S. A. Kerk, P. Sajjakulnukit, A. Myers, G. Thurston, S. Hou, E. S. Carpenter, A. Andren, Z. Nwosu, N. Cusmano, S. Wisner, , C. A. Lyssiotis

This study shows that inhibiting GOT1 in pancreatic cancer primes cells for ferroptosis by promoting autophagy-mediated release of labile iron.

bioRxiv · Feb 28, 2020 · PreprintCancer Biology