Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophages
S. R. Bryden, M. Pingen, D. R. Lefteri, J. Major, L. Delang, S. Jacobs, R. Abdelnabi, J. Neyts, J. Miltenburg, H. Khalid, A. Tuplin, A. Merits, E. Pondeville, J. Edgar, G. J. Graham, , C. McKimmie
The paper shows that activating innate immune responses at the mosquito bite site, specifically targeting skin-resident macrophages, can inhibit systemic arbovirus dissemination and improve clinical outcomes.
bioRxiv · Mar 4, 2019Immunology