G. J. Graham

CXCR2 inhibition enables NASH-HCC immunotherapy

This study shows that combining CXCR2 inhibition with anti-PD1 therapy enhances immunotherapy response in NASH-HCC by reprogramming tumor-associated neutrophils.

Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice

This study generates multi-chemokine receptor reporter mice to analyze receptor expression dynamics on myeloid cells, revealing high specificity and selectivity in chemokine receptor expression.

Maturation, developmental site, and pathology dictate murine neutrophil function

This study identifies Ly6G expression levels as a marker for neutrophil maturation stages and shows spleen-derived neutrophils mature faster with distinct transcriptional profiles.

Diverse myeloid cells are recruited to the developing and inflamed mammary gland

The paper identifies diverse myeloid cell recruitment in developing and inflamed mammary glands and shows inflammation alters terminal end bud abundance during puberty.

Sorting for CCR7-positivity enriches for a dendritic cell population with enhanced antigen-presenting capacity and anti-tumour potency

This study shows that selecting dendritic cells with high CCR7 expression improves their ability to migrate to lymph nodes and enhance anti-tumour immune responses in melanoma models.

Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophages

The paper shows that activating innate immune responses at the mosquito bite site, specifically targeting skin-resident macrophages, can inhibit systemic arbovirus dissemination and improve clinical outcomes.

The chemokine receptor CXCR2 contributes to murine adipocyte development

This study shows that CXCR2 deficiency in mice leads to reduced subcutaneous adipose tissue due to smaller adipocytes, primarily in females.