Author

J. Major

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

I. Gaska· 2 shared J. Al-Bassam· 2 shared L. Gheber· 2 shared S. Inagaki· 2 shared S. T. Forth· 2 shared T. Bodrug· 2 shared A. Alfieri· 1 shared A. F. Thompson· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersCell Biology

I. Gaska

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The mechanochemical origins of the microtubule sliding motility within the kinesin-5 domain organization

S. Nithiananatham, M. K. Iwanski, I. Gaska, H. Pandey, T. Bodrug, S. Inagaki, J. Major, G. Brouhard, L. Gheber, S. S. Rosenfeld, S. T. Forth, A. G. Hendricks, J. Al-Bassam

This study investigates how the structural features of kinesin-5, specifically tail-motor domain interactions and minifilament length, influence microtubule sliding motility and spindle organization.

bioRxiv · Oct 12, 2021 · PreprintCell Biology

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

J. Major, S. Crotta, M. Llorian, T. M. McCabe, H. H. Gad, R. Hartmann, A. Wack

This study shows that type I and III interferons impair lung epithelial repair during viral infection recovery, increasing disease severity and bacterial susceptibility.

bioRxiv · May 5, 2020Immunology

SR-B1 uptake of HDL promotes prostate cancer proliferation and tumor progression

C. A. Traughber, E. Opoku, G. Brubaker, J. Major, H. Lu, S. W. Lorkowski, C. Neumann, A. Hardaway, Y.-M. Chung, K. Gulshan, N. Sharifi, J. M. Brown, J. D. Smith

bioRxiv · Feb 24, 2020 · PreprintCancer Biology

The Kinesin-5 Tail Domain Directly Modulates the Mechanochemical Cycle of the Motor for Anti-Parallel Microtubule Sliding

T. Bodrug, E. Wilson-Kubalek, S. Nithianantham, A. F. Thompson, A. Alfieri, I. Gaska, J. Major, G. Debs, S. Inagaki, P. Gutierrez, L. Gheber, R. McKenney, C. Sindelar, R. Milligan, J. Stumpff, , J. Al-Bassam

This study shows the kinesin-5 tail domain regulates motor activity by modulating ATP hydrolysis and microtubule sliding, leading to slow motility and force generation.

bioRxiv · Aug 8, 2019Biophysics

Pan-viral protection against arboviruses by targeting inoculation site-based skin macrophages

S. R. Bryden, M. Pingen, D. R. Lefteri, J. Major, L. Delang, S. Jacobs, R. Abdelnabi, J. Neyts, J. Miltenburg, H. Khalid, A. Tuplin, A. Merits, E. Pondeville, J. Edgar, G. J. Graham, , C. McKimmie

The paper shows that activating innate immune responses at the mosquito bite site, specifically targeting skin-resident macrophages, can inhibit systemic arbovirus dissemination and improve clinical outcomes.

bioRxiv · Mar 4, 2019Immunology