Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers
R. C. Centore, L. M. M. Soares, S. Topal, R. G. Vaswani, K. Ichikawa, Z. Li, H. Fan, J. W. Setser, D. L. Lahr, L. E. Zawadzke, X. Chen, K. D. Barnash, J. Muwanguzi, N. Anthony, G. J. Sandoval, , S. F. Bellon
This study identifies and characterizes inhibitors of SMARCA4/SMARCA2 ATPases, showing their ability to induce lineage-specific chromatin changes and tumor regression in uveal melanoma.
bioRxiv · Sep 11, 2023 · PreprintCancer Biology