Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes
Y. Sun, M. C. Young, C. H. Woodward, J. N. Danon, H. V. Truong, S. Gupta, T. J. Winters, G. Burslem, N. G. Sgourakis
This paper introduces engineered MHC-I molecules with enhanced stability and peptide exchange capabilities across multiple HLA allotypes, enabling improved antigen screening and TCR analysis.
bioRxiv · Mar 18, 2023Biochemistry