Author

M. C. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Organism:Arabidopsis· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

N. G. Sgourakis· 3 shared C. H. Woodward· 2 shared G. D. Ebel· 2 shared G. F. Papadaki· 2 shared H. V. Truong· 2 shared K. L. Pabilonia· 2 shared M. Nehring· 2 shared N. Ehrhart· 2 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

N. G. Sgourakis

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Optical Control of Cell-Surface and Endomembrane-Exclusive β-Adrenergic Receptor Signaling

W. Thotamune, S. Ubeysinghe, K. K. Shrestha, M. E. Mostafa, M. C. Young, A. Karunarathne

This paper introduces OptoIso, a photo-labile ligand that selectively activates βAR signaling at the cell surface or endomembranes using blue light, enabling precise study of its role in cardiac pathology.

bioRxiv · Feb 14, 2024Biochemistry

A Chicken Tapasin ortholog can chaperone empty HLA molecules independently of other peptide-loading components

G. F. Papadaki, C. H. Woodward, M. C. Young, T. J. Winters, G. M. Burslem, N. G. Sgourakis

This study shows that chicken Tapasin can stabilize human HLA molecules without co-chaperones and can bind peptides, suggesting its use in engineering MHC-I ligand exchange.

bioRxiv · Jun 23, 2023 · PreprintImmunology

Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion

Y. Sun, T. J. Florio, S. Gupta, M. C. Young, Q. F. Marshall, S. E. Garfinkle, G. F. Papadaki, H. V. Truong, E. Mycek, P. Li, A. Farrel, N. L. Church, S. Jabar, M. D. Beasley, B. R. Kiefel, , N. G. Sgourakis

This paper determines the structure of a peptide-centric Chimeric Antigen Receptor (PC-CAR) complex and identifies structural principles for antigen recognition across multiple HLA allotypes.

bioRxiv · May 24, 2023Biochemistry

Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes

Y. Sun, M. C. Young, C. H. Woodward, J. N. Danon, H. V. Truong, S. Gupta, T. J. Winters, G. Burslem, N. G. Sgourakis

This paper introduces engineered MHC-I molecules with enhanced stability and peptide exchange capabilities across multiple HLA allotypes, enabling improved antigen screening and TCR analysis.

bioRxiv · Mar 18, 2023Biochemistry

Impact of prior infection on SARS-CoV-2 antibody responses in vaccinated long-term care facility staff

E. N. Gallichotte, M. Nehring, S. Stromberg, M. C. Young, A. Snell, J. B. Daniels, K. L. Pabilonia, S. Vandewoude, N. Ehrhart, G. D. Ebel

This study examines how prior SARS-CoV-2 infection affects antibody responses to vaccination in long-term care facility staff, finding higher antibody levels in previously infected individuals and no booster response in those with prior immunity.

bioRxiv · Apr 4, 2022Immunology

Durable antibody responses in staff at two long-term care facilities, during and post SARS-CoV-2 outbreaks

E. Gallichotte, M. Nehring, M. C. Young, S. Pugh, N. R. Sexton, E. Fitzmeyer, K. M. Quicke, M. Richardson, K. L. Pabilonia, N. Ehrhart, S. VandeWoude, G. D. Ebel

The paper examines antibody responses in long-term care facility staff during and after SARS-CoV-2 outbreaks, finding durable neutralizing antibodies and potential herd immunity.

bioRxiv · May 4, 2021Immunology

Title - Impact of extrinsic incubation temperature on natural selection during Zika virus infection of Aedes aegypti

R. Murrieta, S. M. Garcia-Luna, D. J. Murrieta, G. Halladay, M. C. Young, J. R. Fauver, A. Gendernalik, J. Weger-Lucarelli, C. Rückert, G. Ebel

This study examines how constant and fluctuating temperatures affect Zika virus transmission and genetic diversity in Aedes mosquitoes.

bioRxiv · Mar 2, 2021 · PreprintMicrobiology