Hydrogels Containing Gradients in Vascular Density Reveal Dose-Dependent Role of Angiocrine Cues on Stem Cell Behavior
M. T. Ngo, V. R. Barnhouse, A. E. Gilchrist, C. J. Hunter, J. N. Hensold, B. A. C. Harley
This study uses 3D hydrogels with vascular density gradients to show how angiocrine cues affect HSC behavior, finding that high vessel density reduces Akt signaling and increases lineage-positive cell expansion.
bioRxiv · Feb 12, 2021Bioengineering