Author

A. E. Gilchrist

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Assay:organoid / primary culture· 3 Research Focus:clustering· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

B. Harley· 3 shared M. T. Ngo· 2 shared A. R. Smith· 1 shared B. A. C. Harley· 1 shared B. A. Krajina· 1 shared B. L. LeSavage· 1 shared C. Curtis· 1 shared C. J. Hunter· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersBioengineering

B. Harley

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Engineered extracellular matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids

B. L. LeSavage, A. E. Gilchrist, B. A. Krajina, K. Karlsson, A. R. Smith, K. Karagyozova, K. C. Klett, C. Curtis, C. J. Kuo, S. C. Heilshorn

This study shows that high stiffness engineered matrices induce chemoresistance in pancreatic cancer organoids through hyaluronan mechanosignaling and a plastic cancer stem cell phenotype.

bioRxiv · Apr 22, 2022 · PreprintCancer Biology

Encapsulation and recovery of murine hematopoietic stem and progenitor cells in a thiol-crosslinked maleimide-functionalized gelatin hydrogel

A. E. Gilchrist, J. F. Serrano, M. T. Ngo, Z. Hrnjak, S. Kim, B. Harley

This paper develops a GelMAL hydrogel for encapsulating stem cells with tunable properties and cleavable crosslinks, preserving stem cell markers.

bioRxiv · Mar 22, 2021Bioengineering

Hydrogels Containing Gradients in Vascular Density Reveal Dose-Dependent Role of Angiocrine Cues on Stem Cell Behavior

M. T. Ngo, V. R. Barnhouse, A. E. Gilchrist, C. J. Hunter, J. N. Hensold, B. A. C. Harley

This study uses 3D hydrogels with vascular density gradients to show how angiocrine cues affect HSC behavior, finding that high vessel density reduces Akt signaling and increases lineage-positive cell expansion.

bioRxiv · Feb 12, 2021Bioengineering

Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche

A. E. Gilchrist, B. Harley

The paper identifies cytokine cocktails that enhance hematopoietic stem cell maintenance in an engineered niche using proteomic analysis and computational methods.

bioRxiv · Jan 19, 2020Bioengineering

Mesenchymal stromal cell remodeling of a gelatin hydrogel microenvironment defines an artificial hematopoietic stem cell niche

A. E. Gilchrist, S. Lee, Y. Hu, B. Harley

This study develops a GelMA hydrogel system with co-encapsulated MSCs to enhance HSC maintenance and quiescence through dynamic matrix remodeling and signaling balance.

bioRxiv · Feb 13, 2019 · PreprintBioengineering