Activation of IP3R in atrial cardiomyocytes leads to generation of cytosolic cAMP
E. C. Akerman, M. J. Read, S. J. Bose, A. Koschinski, R. A. Capel, Y.-C. Chao, M. Folkmanaite, S. Hester, R. Fischer, T. Ayagama, S. D. Broadbent, R. Ahamed, J. N. Simon, D. A. Terrar, M. Zaccolo, R.-A. B. Burton
This study shows that IP3R activation in atrial myocytes increases cAMP, which can be inhibited by IP3R blockers, but ventricular myocytes show cAMP increases independent of IP3R.
bioRxiv · Mar 28, 2024Physiology