Author

D. A. Terrar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:rat· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

M. Zaccolo· 3 shared R. A. Capel· 3 shared S. J. Bose· 3 shared T. Ayagama· 3 shared A. D. Grassam-Rowe· 1 shared A. Koschinski· 1 shared A. M. Ibrahim· 1 shared A. Russell· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersPhysiology

M. Zaccolo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Activation of IP3R in atrial cardiomyocytes leads to generation of cytosolic cAMP

E. C. Akerman, M. J. Read, S. J. Bose, A. Koschinski, R. A. Capel, Y.-C. Chao, M. Folkmanaite, S. Hester, R. Fischer, T. Ayagama, S. D. Broadbent, R. Ahamed, J. N. Simon, D. A. Terrar, M. Zaccolo, R.-A. B. Burton

This study shows that IP3R activation in atrial myocytes increases cAMP, which can be inhibited by IP3R blockers, but ventricular myocytes show cAMP increases independent of IP3R.

bioRxiv · Mar 28, 2024Physiology

Generation of cardiomyocytes from human induced pluripotent stem cells resembling atrial cells with ability to respond to adrenoceptor agonists

F. S. Ahmad, Y. Jin, A. D. Grassam-Rowe, Y. Zhou, M. Yuan, X. Fan, R. Zhou, R. Mu-u-min, C. O'Shea, A. M. Ibrahim, W. Hyder, Y. Aguib, M. Yacoub, D. Pavlovic, Y. Zhang, , M. Lei

This paper describes a method to generate human atrial-like cardiomyocytes from induced pluripotent stem cells that respond to adrenoceptor agonists.

bioRxiv · Jul 20, 2022 · PreprintBioengineering

Cross-talk between cAMP and Ca2+ signalling in cardiac pacemaker cells involves IP3-evoked Ca2+ release and stimulation of adenylyl cyclase 1

S. J. Bose, M. Read, R. A. Capel, E. Akerman, T. Ayagama, A. Russell, D. A. Terrar, M. Zaccolo, R. A. B. Burton

This study investigates the role of AC1 in atrial pacemaker activity response to β-adrenergic stimulation and IP3R calcium release in mouse and guinea pig atrial tissues.

bioRxiv · Jan 6, 2022 · PreprintPharmacology & Toxicology

cAMP signalling is required for the actions of IP3 on Ca2+-transients in cardiac atria and beating rate in sino-atrial node

R. A. Capel, T. Collins, S. J. Bose, S. Rajasundaram, T. Ayagama, M. Zaccolo, R. A. Burton, D. A. Terrar

The paper investigates the interaction between IP3 and cAMP signaling in cardiac atria and sino-atrial node, showing that IP3 enhances Ca2+ transients and beating rate through AC activation.

bioRxiv · Jul 24, 2019 · PreprintPhysiology