Author

S. J. Bose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:development & morphogenesis· 2 Assay:electrophysiology· 2 Organism:mouse· 2 Organism:rat· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

D. A. Terrar· 3 shared M. Zaccolo· 3 shared R. A. Capel· 3 shared T. Ayagama· 3 shared R. A. Burton· 2 shared A. Bueno-Orovio· 1 shared A. Galione· 1 shared A. Koschinski· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersPhysiology

D. A. Terrar

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Activation of IP3R in atrial cardiomyocytes leads to generation of cytosolic cAMP

E. C. Akerman, M. J. Read, S. J. Bose, A. Koschinski, R. A. Capel, Y.-C. Chao, M. Folkmanaite, S. Hester, R. Fischer, T. Ayagama, S. D. Broadbent, R. Ahamed, J. N. Simon, D. A. Terrar, M. Zaccolo, R.-A. B. Burton

This study shows that IP3R activation in atrial myocytes increases cAMP, which can be inhibited by IP3R blockers, but ventricular myocytes show cAMP increases independent of IP3R.

bioRxiv · Mar 28, 2024Physiology

Lysosomal calcium loading promotes arrhythmias by potentiating ryanodine receptor release

Z. Meng, R.-A. Capel, S. J. Bose, E. Bosch, S. d. Jong, R. Planque, A. Galione, R. A. Burton, A. Bueno-Orovio

This study shows lysosomal calcium handling promotes RyR spontaneous release by increasing SR-junction calcium gradient, and blocking lysosomal function reduces arrhythmias.

bioRxiv · Nov 9, 2022 · PreprintBiophysics

Cross-talk between cAMP and Ca2+ signalling in cardiac pacemaker cells involves IP3-evoked Ca2+ release and stimulation of adenylyl cyclase 1

S. J. Bose, M. Read, R. A. Capel, E. Akerman, T. Ayagama, A. Russell, D. A. Terrar, M. Zaccolo, R. A. B. Burton

This study investigates the role of AC1 in atrial pacemaker activity response to β-adrenergic stimulation and IP3R calcium release in mouse and guinea pig atrial tissues.

bioRxiv · Jan 6, 2022 · PreprintPharmacology & Toxicology

cAMP signalling is required for the actions of IP3 on Ca2+-transients in cardiac atria and beating rate in sino-atrial node

R. A. Capel, T. Collins, S. J. Bose, S. Rajasundaram, T. Ayagama, M. Zaccolo, R. A. Burton, D. A. Terrar

The paper investigates the interaction between IP3 and cAMP signaling in cardiac atria and sino-atrial node, showing that IP3 enhances Ca2+ transients and beating rate through AC activation.

bioRxiv · Jul 24, 2019 · PreprintPhysiology