Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells
J. Wang, H. Filippakis, T. Hougard, H. Du, C. Ye, H.-J. Liu, L. Zhang, K. Hindi, S. Bagwe, J. Nijmeh, J. M. Asara, W. Shi, S. Y. El-Chemaly, E. P. Henske, H. C. Lam
This study shows that IL-6 promotes PSAT1 expression and serine metabolism in TSC2-deficient cells, linking IL-6 to mTORC1 hyperactivity and potential therapeutic targets.
bioRxiv · May 17, 2021Pathology