J. M. Asara

The SLC1A1/EAAT3 Dicarboxylic Amino Acid Transporter is an Epigenetically Dysregulated Nutrient Carrier that Sustains Oncogenic Metabolic Programs

This study identifies SLC1A1/EAAT3 as an oncogenic transporter in ccRCC driven by H3K27ac, showing its role in sustaining metabolic programs and its potential as a therapeutic target.

Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism

This study shows that angiogenesis inhibitors enhance the effectiveness of metabolic therapies in gliomas by inducing anaplerotic nutrient stress.

NAD+ biosynthesis as a collateral lethality target for precision oncology

The paper identifies NMNAT2 as a collateral lethality target in cancers with NMNAT1 deletions, showing selective toxicity in vitro and tumor eradication in vivo.

Wild-type IDH1 inhibition enhances chemotherapy response in melanoma

This study shows that inhibiting wild-type IDH1 enhances chemotherapy response in melanoma by reducing redox homeostasis and increasing reactive oxygen species.

De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

Non-conserved metabolic regulation by LKB1 distinguishes human and mouse lung adenocarcinoma

This study identifies a metabolic divergence between human and mouse lung adenocarcinomas due to LKB1-dependent regulation of TPI1 phosphorylation, highlighting limitations of mouse models for studying human cancer.

Comparative untargeted metabolomic profiling of induced mitochondrial fusion in pancreatic cancer

The paper compares metabolic changes induced by three methods of mitochondrial fusion in pancreatic cancer cells and identifies common amino acid metabolism alterations.

Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells

This study shows that IL-6 promotes PSAT1 expression and serine metabolism in TSC2-deficient cells, linking IL-6 to mTORC1 hyperactivity and potential therapeutic targets.

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

This study shows that mTORC1 activates ATF4 in the liver to regulate amino acid metabolism during feeding and insulin signaling.

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

This study shows that mTORC1 activates ATF4 to promote protein and glutathione synthesis, distinct from ISR-mediated ATF4 activation.

Age-induced methylmalonic acid accumulation promotes tumor progression and aggressiveness

The paper shows that methylmalonic acid accumulation with age promotes tumor progression by inducing SOX4 and reprogramming cancer cells.

Proteomics of protein trafficking by in vivo tissue-specific labeling

The paper develops an in vivo platform to study secreted protein trafficking between organs, identifies interorgan communication factors, and finds conserved adipokines affecting muscle activity.

GOT1 Inhibition Primes Pancreatic Cancer for Ferroptosis through the Autophagic Release of Labile Iron

This study shows that inhibiting GOT1 in pancreatic cancer primes cells for ferroptosis by promoting autophagy-mediated release of labile iron.

Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy

This study shows that inhibiting ODC with DFMO sensitizes TNBC cells to chemotherapy, but not receptor-positive breast cancer cells.

IMPDH inhibitors for anti-tumor therapy in tuberous sclerosis complex

This paper evaluates IMPDH inhibitors for anti-tumor therapy in TSC, finding mizoribine more effective than mycophenolic acid in targeting mTORC1-driven tumors.

Methylthioadenosine is Not Dramatically Elevated in MTAP-Homozygous Deleted Primary Glioblastomas

This paper shows that MTA levels are not significantly elevated in MTAP-homozygous deleted primary human glioblastomas, challenging the clinical relevance of targeting PRMT5 and MAT2A in these tumors.

Tissue of Origin Dictates GOT1 Dependence and Confers Synthetic Lethality to Radiotherapy

The paper shows that pancreatic ductal adenocarcinoma (PDA) is more dependent on GOT1 than colorectal cancer (CRC) and that GOT1 inhibition synergizes with radiotherapy to inhibit PDA growth.

Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer

The paper identifies CDO1 as a metabolic liability in NSCLC by showing its silencing promotes proliferation through cysteine metabolism disruption.