J. O. Aponte-Serrano

This paper develops a method to convert non-spatial ODE models into spatial, agent-based models for multicellular systems, demonstrating applications in viral infection and showing how spatial models can reveal hidden biophysical mechanisms.

The paper introduces a modular simulation platform to model viral infection and immune response in epithelial tissue, showing that early low-dose antiviral treatment is more effective than late high-dose treatment.

This paper introduces a virtual tissue platform to simulate tumor growth and immune response, demonstrating its utility in optimizing immunotherapy based on patient fitness.