Author

J. A. Glazier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 5 Approach:statistical model· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Approach:experimental assay· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

T. J. Sego· 3 shared J. Ferrari Gianlupi· 2 shared J. O. Aponte-Serrano· 2 shared A. F. Thompson· 1 shared A. Schug· 1 shared A. Wandinger-Ness· 1 shared B.-S. Herbert· 1 shared C. D. Wells· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCell Biology

T. J. Sego

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A spatialised agent-based model of NOTCH signalling pathway in Endothelial Cells predicts emergent heterogeneity due to continual dynamic phenotypic adjustments.

F. Chesnais, T. J. Sego, E. Engstler, M. Battilocchi, D. Danovi, J. A. Glazier, L. Veschini

The paper uses a spatialised agent-based model to show NOTCH signalling pathway dynamics in endothelial cells can generate spatial heterogeneity through oscillations and phenotypic adjustments.

bioRxiv · Aug 6, 2022 · PreprintCell Biology

Reconstitution of renal cyst formation in 3D culture reveals a role for AMOT and Yap1 in determining cyst size.

C. D. Wells, K. Lange, A. F. Thompson, W. M. Xu, S. G. Clendenon, J. S. Underwood, P. Harris, B.-S. Herbert, J. A. Glazier, A. Wandinger-Ness, R. L. Bacallao

The paper shows that Cadherin 8 and YAP1 drive cyst initiation and expansion, respectively, in 3D kidney cultures, with AMOTL1 inhibiting expansion.

bioRxiv · Mar 1, 2022 · PreprintCell Biology

Mechanical influences on in silico tumor evolution

J. Rosenbauer, M. Berghoff, J. A. Glazier, A. Schug

This paper uses computational modeling to show that mechanical fluctuations in nutrient supply can accelerate tumor evolution by favoring low-adhesion cells.

bioRxiv · Mar 23, 2021 · PreprintCancer Biology

Generating Agent-Based Multiscale Multicellular Spatiotemporal Models from Ordinary Differential Equations of Biological Systems, with Applications in Viral Infection

T. J. Sego, J. O. Aponte-Serrano, J. Ferrari Gianlupi, J. A. Glazier

This paper develops a method to convert non-spatial ODE models into spatial, agent-based models for multicellular systems, demonstrating applications in viral infection and showing how spatial models can reveal hidden biophysical mechanisms.

bioRxiv · Jan 28, 2021 · PreprintBiophysics

A Modular Framework for Multiscale Spatial Modeling of Viral Infection and Immune Response in Epithelial Tissue

T. J. Sego, J. O. Aponte-Serrano, J. Ferrari Gianlupi, S. Heaps, K. Breithaupt, L. Brusch, J. Crawshaw, J. M. Osborne, E. M. Quardokus, R. K. Plemper, J. A. Glazier

The paper introduces a modular simulation platform to model viral infection and immune response in epithelial tissue, showing that early low-dose antiviral treatment is more effective than late high-dose treatment.

PLOS Computational Biology · Dec 21, 2020Peer-reviewedBioengineering

Development of a Coupled Simulation Toolkit for Computational Radiation Biology Based on Geant4 and CompuCell3D

R. Liu, K. A. Higley, M. J. Swat, M. A. Chaplain, G. Powathil, J. A. Glazier

This paper introduces a coupled simulation toolkit combining Geant4 and CompuCell3D to model radiation effects on tissue, enabling simulation of tumor response to radiation therapy.

bioRxiv · Apr 9, 2020Biophysics