Author

J. M. Osborne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. J. Langlands· 1 shared A. Zanca· 1 shared D. P. J. Germano· 1 shared E. M. Quardokus· 1 shared I. Nathke· 1 shared I. P. Newton· 1 shared J. A. Flegg· 1 shared J. A. Glazier· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. J. Langlands

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3 papers

Recent·Most cited

Free and interfacial boundaries in individual-based models of multicellular biological systems

D. P. J. Germano, A. Zanca, S. T. Johnston, J. A. Flegg, J. M. Osborne

This study investigates how different cell boundary descriptions affect population dynamics in individual-based models of multicellular systems, finding that Voronoi tessellation is most sensitive and overlapping spheres couples timescale to boundary description.

bioRxiv · Dec 13, 2022Biophysics

A Modular Framework for Multiscale Spatial Modeling of Viral Infection and Immune Response in Epithelial Tissue

T. J. Sego, J. O. Aponte-Serrano, J. Ferrari Gianlupi, S. Heaps, K. Breithaupt, L. Brusch, J. Crawshaw, J. M. Osborne, E. M. Quardokus, R. K. Plemper, J. A. Glazier

The paper introduces a modular simulation platform to model viral infection and immune response in epithelial tissue, showing that early low-dose antiviral treatment is more effective than late high-dose treatment.

PLOS Computational Biology · Dec 21, 2020Peer-reviewedBioengineering

Postmitotic Separation Enables Selective Niche Retention Of One Daughter Cell In Intestinal Crypts And Is Facilitated By Interkinetic Nuclear Migration And Basal Tethering

T. Carroll, A. J. Langlands, J. M. Osborne, I. P. Newton, P. L. Appleton, I. Nathke

The paper shows that postmitotic separation of intestinal crypt cells leads to niche retention of one daughter cell, and this process is disrupted in Apc mutant cells.

bioRxiv · May 26, 2017Cancer Biology